Are Anticoagulants Useful for CKD Patients with Atrial Fibrillation?

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Anticoagulants don’t reduce the risk of stroke in older adults with atrial fibrillation and chronic kidney disease, suggests a study in Kidney International.

The researchers analyzed data on 6544 Ontario residents aged 66 years or older with advanced CKD—estimated glomerular filtration rate less than 45 mL/min/1.73 m2—and atrial fibrillation. Of these, 1475 filled an anticoagulant prescription, mainly for vitamin K antagonists. Propensity matching was used to identify 1417 matched pairs with or without anticoagulation; median follow-up was 269 and 254 days, respectively. Risks of ischemic stroke, hemorrhagic events, or death were compared between groups.

The rate

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