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Volume/Issue:
Volume 6: Issue 7
Page:
7
Publication Date:
01 Jul 2014
Online Publication Date:
31 Aug 2015
  • Figure 1.
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    Figure 1.

    Proposed classification scheme for MPGN into immune complex–mediated and complement-mediated MPGN, based on immunofluorescence microscopy (IF) findings. Immune complex–mediated MPGN is characterized by the presence of immunoglobulins (Ig) and/or C3, while complement-mediated MPGN is characterized by the presence of bright C3 and absent/scant Ig. Evaluation of immune complex–mediated MPGN should include work-up for monoclonal gammopathy, autoimmune diseases, and infections. On the other hand, evaluation of complement-mediated MPGN should include work-up for functional, acquired, and inherited abnormalities of the alternative pathway of complement.

Figure 1.

Proposed classification scheme for MPGN into immune complex–mediated and complement-mediated MPGN, based on immunofluorescence microscopy (IF) findings. Immune complex–mediated MPGN is characterized by the presence of immunoglobulins (Ig) and/or C3, while complement-mediated MPGN is characterized by the presence of bright C3 and absent/scant Ig. Evaluation of immune complex–mediated MPGN should include work-up for monoclonal gammopathy, autoimmune diseases, and infections. On the other hand, evaluation of complement-mediated MPGN should include work-up for functional, acquired, and inherited abnormalities of the alternative pathway of complement.
  • 1

    Sethi S , Fervenza FC . Membranoproliferative glomerulonephritis: a new look at an old entity. N Engl J Med 2012; 366:1119−1131.

  • 2

    Sethi S , Fervenza FC . Membranoproliferative glomerulonephritis: pathogenetic heterogeneity and proposal for a new classification. Semin Nephrol 2011; 31:341−348.

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  • 3

    Sethi S , et al.. Membranoproliferative glomerulonephritis secondary to monoclonal gammopathy. Clin J Am Soc Nephrol 2010; 5:770−782.

  • 4

    Zand L , et al.. Membranoproliferative glomerulonephritis associated with autoimmune diseases. J Nephrol 2014; 27:165−171.

  • 5

    Sethi S , et al.. C3 glomerulonephritis: clinicopathological findings, complement abnormalities, glomerular proteomic profile, treatment, and follow-up. Kidney Int 2012; 82:465−473.

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  • 6

    Zand L , et al.. Clinical findings, pathology, and outcomes of C3GN after kidney transplantation. J Am Soc Nephrol 2013 Dec 19 [Epub ahead of print].

Editorial Type:
Special Section

Understanding MPGN In the Native and Transplanted Kidney

Sanjeev Sethi
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Fernando C. Fervenza
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Volume/Issue:
Volume 6: Issue 7
Publication Date:
01 Jul 2014
Page:
7
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