• 1.

    Groenwald HF , Januzzi JL , Damman K , et al.. Anemia and mortality in heart failure patients: a systematic review and meta–analysis. J Am Coll Cardiol 2008; 52:818827.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2.

    He S-W , Wang L-X . The impact of anemia on the prognosis of chronic heart failure: a meta-analysis and systemic review. Congest Heart Fail 2009; 15:123130.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3.

    Anand IS . Anemia and chronic heart failure. J Am Coll Cardiol 2008; 52:501511.

  • 4.

    Silverberg DS , Wexler D , Iaina A , et al.. The correction of anemia in patients with the combination of chronic kidney disease and congestive heart failure may prevent progression of both conditions. Clin Exp Nephrol 2009; 13:101106.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 5.

    Boerrigter G , Costello-Boerrigter LC , Abraham WT , et al.. Cardiac resynchronization therapy improves renal function in human heart failure with reduced glomerular function. J Card Fail 2008; 14:539546.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6.

    Weiss G . Iron metabolism in the anemia of chronic disease. Biochim Biophys Acta 2009; 1790:682693.

  • 7.

    Weiss G , Meusburger E , Radacher G , et al.. Effect of iron treatment on circulating cytokine levels in ESRD patients receiving recombinant human erythropoietin. Kidney Int 2003; 64:572578.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8.

    Vlahakos DV , Marathias KP , Madias NE . The role of the renin angiotensin system in the regulation of erythropoiesis. Am J Kidney Dis 2010;

  • 9.

    Abramov D , Cohen RS , Katz SD , et al.. Comparison of blood volume characteristics in anemic patients with low versus preserved left ventricular ejection fraction. Am J Cardiol 102:10691072.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 10.

    Ngo K , Kotecha D , Walters JA , et al.. Erythropoiesis-stimulating agents for anaemia in chronic heart failure patients. Cochrane Database Syst Rev 2010; Jan 20;(1):CD007613.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 11.

    Ponikowski P , Anker SD , Szachniewicz J , et al.. Effect of darbepoetin alpha on exercise tolerance in anemic patients with symptomatic chronic heart failure. J Am Coll Cardiol 2007; 49:753762.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12.

    Van Veldhuisen DJ , Dickstein K , Cohen-Solal A , et al.. Randomized, double-blind, placebo-controlled study to evaluate the effect of two dosing regimens of darbepoetin alfa in patients with heart failure and anaemia. Eur Heart J 2007; 28:22082216.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13.

    Ghali J , Anand I , Abraham WT , et al.. Randomized double blind trial of darbepoetin alpha treatment in patients with symptomatic heart failure and anemia. Circulation 2008; 117:526535.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14.

    Klapholz M , Abraham WT , Ghali JK , et al.. The safety and tolerability of darbepoetin alfa in patients with and symptomatic heart failure. Eur J Heart Fail 2009; 11:10711077.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 15.

    Abraham WT , Anand IS , Klapholz M , et al.. Treatment of anemia with darbepoetin alfa in heart failure. Congest Heart Fail 2010; 16:8795.

  • 16.

    Arcasoy MO . The non-haematopoietic biological effects of erythropoietin. Br J Haematol 2008; 141:1431.

  • 17.

    Naito Y , Tsujino T , Matsumoto M , et al.. Adaptive response of the heart to long term anemia induced by iron deficiency. Am J Physiol Heart Circ Physiol 2009; 296:H585593.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 18.

    Dong F , Zhang X , Culver B , et al.. Dietary iron deficiency induces ventricular dilation, mitochondrial ultrastructural aberrations and cytochrome C release: involvement of nitric oxide synthase and protein tyrosine nitration. Clin Sci 2005; 109:277286.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 19.

    Murphy CL , Fitzimmons RJ , Jardine AJ , et al.. Routine assessment of iron status in all patients with heart failure may identify those at risk of developing anemia. Eur J Heart Fail 2007; 61:103.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 20.

    Grzeslo, Jankowska EA , Witkowski J et al.. Iron deficiency is a common finding in patients with stable chronic heart failure. Eur J Heart Fail (suppl) 2006; 5:132.

  • 21.

    De Silva R , Rigby AS , Klaus KA , et al.. Anemia, renal dysfunction, and their interaction in patients with chronic heart failure. Am J Cardiol 2006; 98:391398.

  • 22.

    Opasich C , Cazzola M , Scelsi L , et al.. Blunted erythropoietin production and defective iron supply for erythropoiesis as major causes of in patients with chronic heart failure. Eur Heart J 2005; 26:22322237.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 23.

    Nanas JN , Matsouka C , Karageorgopoulos D , et al.. Etiology of anemia in patients with advanced heart failure. J Am Coll Cardiol 2006; 48:24852489.

  • 24.

    Bolger AP , Bartlett FP , Penston HS , et al.. Intravenous iron alone for the treatment of anemia in patients with chronic heart failure. J Am Coll Cardiol 2006; 48:12251227.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 25.

    Usmanov RI , Zueva EB , Silverberg DS , et al.. Intravenous iron without erythropoietin for the treatment of iron deficiency anemia in patients with moderate to severe congestive heart failure and chronic renal insufficiency. J Nephrol 2006; 21:236242.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 26.

    Toblli J , Lombrana A , Duarte P , et al.. Intravenous iron reduces NT- pro-BNP in anemic patients with chronic heart failure and renal insufficiency. J Am Coll Cardiol 2007; 50:16571665.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 27.

    Okonko DO , Grzeslo A , Witkowski T , et al.. Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency. J Am Coll Cardiol 2008; 51:103112.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 28.

    Anker SD , Comin Colet J , Fillipatos G , et al.. Ferric carboxymaltose in patients with heart failure and iron deficiency. N Engl J Med 2009; 361:24362448.

  • 29.

    Rozen-Zvi B , Gafter-Gvili A , Paul M , et al.. Intravenous versus oral iron supplementation for the treatment of anemia in CKD: systematic review and meta-analysis. Am J Kidney Dis 2008; 52:897906.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 30.

    McMurray JJV , Anand IS , Diaz R , et al.. Design of the reduction of events with darbepoetin alfa in Heart Failure (RED-HF): a phase III, anemia correction morbidity-mortality trial. Eur J Heart Fail 2009; 11:795801.

    • PubMed
    • Search Google Scholar
    • Export Citation

Anemia Management in Cardiorenal Disease

By Donald S. Silverberg
Search for other papers by By Donald S. Silverberg in
Current site
Google Scholar
PubMed
Close
,
Dov Wexler
Search for other papers by Dov Wexler in
Current site
Google Scholar
PubMed
Close
,
Adrian Iaina
Search for other papers by Adrian Iaina in
Current site
Google Scholar
PubMed
Close
, and
Doron Schwartz
Search for other papers by Doron Schwartz in
Current site
Google Scholar
PubMed
Close
Restricted access
Save