BeethamKS, Effect of a 3-year lifestyle intervention in patients with chronic kidney disease: A randomized clinical trial. J Am Soc Nephrol 2022; 33:431–441. doi: 10.1681/ASN.202105066810.1681/ASN.2021050668)| false
RossiAP, Effects of a renal rehabilitation exercise program in patients with CKD: A randomized, controlled trial. Clin J Am Soc Nephrol 2014; 9:2052–2058. doi: 10.2215/CJN.1179111310.2215/CJN.11791113)| false
IkizlerTA, Metabolic effects of diet and exercise in patients with moderate to severe CKD: A randomized clinical trial. J Am Soc Nephrol 2018; 29:250–259. doi: 10.1681/ASN.201701002010.1681/ASN.2017010020)| false
1 Patrick C. Ahearn, MD, MAS, and Xingxing S. Cheng, MD, MS, are Clinical Assistant Professors with the Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Stanford, CA.
Chronic kidney disease (CKD) is associated with physical function decline and worsening comorbidity burden. A recent study published in the Journal of the American Society of Nephrology (1) reports findings from the LANDMARK III study, a years-long, longitudinal randomized study of a multi-disciplinary, clinic-based and lifestyle intervention for Australian patients with CKD stages 3a−4. The intensive intervention required a treatment team of nurse practitioners, exercise physiologists, dieticians, diabetes educators, psychologists, and nephrologists. Risk factors addressed included blood pressure, weight, and cardiorespiratory fitness. The 81 intervention-group patients attended 4 weeks of behavior and lifestyle intervention and 8