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    Hodgin JB, et al. Quantification of glomerular structural lesions: Associations with clinical outcomes and transcriptomic profiles in nephrotic syndrome. Am J Kidney Dis [published online ahead of print December 2, 2021]. doi: 10.1053/j.ajkd.2021.10.004; https://www.ajkd.org/article/S0272-6386(21)01004-0/fulltext

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    Barisoni L, et al. Digital pathology evaluation in the multicenter Nephrotic Syndrome Study Network (NEPTUNE). Clin J Am Soc Nephrol 2013; 8:14491459. doi: 10.2215/CJN.08370812

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The Nephrotic Syndrome Study Network (NEPTUNE): Heterogeneity Becomes an Opportunity

Laura H. Mariani Laura H. Mariani, MD, MS; Debbie S. Gipson, MD; and Matthias Kretzler, MD, are with the Department of Internal Medicine, Division of Nephrology, University of Michigan Health, Michigan Medicine, Ann Arbor. Laura Barisoni, MD, is with the Department of Pathology and Medicine, Division of Nephrology, Duke University School of Medicine, Durham, NC. Lawrence B. Holzman, MD, is with the Department of Medicine, Renal-Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia. Crystal Gadegbeku, MD, is with the Department of Kidney Medicine, Glickman Urological and Kidney Institute, Cleveland Clinic Health System, Cleveland, OH. John R. Sedor, MD, is with the Department of Kidney Medicine, Glickman Urological and Kidney Institute, Cleveland Clinic Health System, and the Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH.

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Laura Barisoni Laura H. Mariani, MD, MS; Debbie S. Gipson, MD; and Matthias Kretzler, MD, are with the Department of Internal Medicine, Division of Nephrology, University of Michigan Health, Michigan Medicine, Ann Arbor. Laura Barisoni, MD, is with the Department of Pathology and Medicine, Division of Nephrology, Duke University School of Medicine, Durham, NC. Lawrence B. Holzman, MD, is with the Department of Medicine, Renal-Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia. Crystal Gadegbeku, MD, is with the Department of Kidney Medicine, Glickman Urological and Kidney Institute, Cleveland Clinic Health System, Cleveland, OH. John R. Sedor, MD, is with the Department of Kidney Medicine, Glickman Urological and Kidney Institute, Cleveland Clinic Health System, and the Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH.

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Debbie S. Gipson Laura H. Mariani, MD, MS; Debbie S. Gipson, MD; and Matthias Kretzler, MD, are with the Department of Internal Medicine, Division of Nephrology, University of Michigan Health, Michigan Medicine, Ann Arbor. Laura Barisoni, MD, is with the Department of Pathology and Medicine, Division of Nephrology, Duke University School of Medicine, Durham, NC. Lawrence B. Holzman, MD, is with the Department of Medicine, Renal-Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia. Crystal Gadegbeku, MD, is with the Department of Kidney Medicine, Glickman Urological and Kidney Institute, Cleveland Clinic Health System, Cleveland, OH. John R. Sedor, MD, is with the Department of Kidney Medicine, Glickman Urological and Kidney Institute, Cleveland Clinic Health System, and the Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH.

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Lawrence B. Holzman Laura H. Mariani, MD, MS; Debbie S. Gipson, MD; and Matthias Kretzler, MD, are with the Department of Internal Medicine, Division of Nephrology, University of Michigan Health, Michigan Medicine, Ann Arbor. Laura Barisoni, MD, is with the Department of Pathology and Medicine, Division of Nephrology, Duke University School of Medicine, Durham, NC. Lawrence B. Holzman, MD, is with the Department of Medicine, Renal-Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia. Crystal Gadegbeku, MD, is with the Department of Kidney Medicine, Glickman Urological and Kidney Institute, Cleveland Clinic Health System, Cleveland, OH. John R. Sedor, MD, is with the Department of Kidney Medicine, Glickman Urological and Kidney Institute, Cleveland Clinic Health System, and the Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH.

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Crystal Gadegbeku Laura H. Mariani, MD, MS; Debbie S. Gipson, MD; and Matthias Kretzler, MD, are with the Department of Internal Medicine, Division of Nephrology, University of Michigan Health, Michigan Medicine, Ann Arbor. Laura Barisoni, MD, is with the Department of Pathology and Medicine, Division of Nephrology, Duke University School of Medicine, Durham, NC. Lawrence B. Holzman, MD, is with the Department of Medicine, Renal-Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia. Crystal Gadegbeku, MD, is with the Department of Kidney Medicine, Glickman Urological and Kidney Institute, Cleveland Clinic Health System, Cleveland, OH. John R. Sedor, MD, is with the Department of Kidney Medicine, Glickman Urological and Kidney Institute, Cleveland Clinic Health System, and the Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH.

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John R. Sedor Laura H. Mariani, MD, MS; Debbie S. Gipson, MD; and Matthias Kretzler, MD, are with the Department of Internal Medicine, Division of Nephrology, University of Michigan Health, Michigan Medicine, Ann Arbor. Laura Barisoni, MD, is with the Department of Pathology and Medicine, Division of Nephrology, Duke University School of Medicine, Durham, NC. Lawrence B. Holzman, MD, is with the Department of Medicine, Renal-Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia. Crystal Gadegbeku, MD, is with the Department of Kidney Medicine, Glickman Urological and Kidney Institute, Cleveland Clinic Health System, Cleveland, OH. John R. Sedor, MD, is with the Department of Kidney Medicine, Glickman Urological and Kidney Institute, Cleveland Clinic Health System, and the Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH.

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Matthias Kretzler Laura H. Mariani, MD, MS; Debbie S. Gipson, MD; and Matthias Kretzler, MD, are with the Department of Internal Medicine, Division of Nephrology, University of Michigan Health, Michigan Medicine, Ann Arbor. Laura Barisoni, MD, is with the Department of Pathology and Medicine, Division of Nephrology, Duke University School of Medicine, Durham, NC. Lawrence B. Holzman, MD, is with the Department of Medicine, Renal-Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia. Crystal Gadegbeku, MD, is with the Department of Kidney Medicine, Glickman Urological and Kidney Institute, Cleveland Clinic Health System, Cleveland, OH. John R. Sedor, MD, is with the Department of Kidney Medicine, Glickman Urological and Kidney Institute, Cleveland Clinic Health System, and the Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH.

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