Boosters for Transplant Patients: Some Reach Protective Antibody Levels

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A third dose of the COVID-19 vaccine achieves protective antibody levels in nearly 40% of kidney transplant recipients without a previous immune response, reports a study in JAMA Internal Medicine (1).

The single-center, single-blind randomized trial included 201 kidney transplant recipients who did not develop SARS-CoV-2 spike protein antibodies after two doses of the mRNA vaccine. Patients were assigned to either a heterologous vaccination strategy using an Ad26COVS1 viral vector vaccine or a homologous strategy with a third dose of an mRNA vaccine, either BNT162b2 or mRNA-1273. The main endpoint was seroconversion to detectable levels of SARS-CoV-2 spike