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Updated Risk Score for Contrast-Associated Acute Kidney Injury: An Opportunity for Action Instead of Renalism

  • 1 Daniel Edmonston, MD, MHS, is with the Division of Nephrology, Duke University, and Duke Clinical Research Institute, Durham, NC. Neha Pagidipati, MD, MPH, is with the Division of Cardiology, Duke University, and Duke Clinical Research Institute, Durham, NC.
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The nomenclature shift from contrast-induced to contrast-associated acute kidney injury (CA-AKI) reflects a waning confidence in the nephrotoxicity of iodinated contrast. Despite early animal and observational data supporting this nephrotoxicity (1, 2), more appropriately controlled and matched studies have failed to demonstrate this link (36). In 2004, Mehran and colleagues (7) developed a risk score to predict CA-AKI in people undergoing percutaneous coronary intervention (PCI). In a recent study published in The Lancet (8), the investigators aimed to update this risk score to reflect more contemporary clinical practices.

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