High Rate of AKI after Treatment for Infected Knee Replacements

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Acute kidney injury (AKI) develops in nearly 1 out of 5 patients treated with antibiotic-loaded “spacers” for periprosthetic infection after total knee arthroplasty (TKA), reports a study in The Journal of Bone and Joint Surgery.

The retrospective study included 424 patients undergoing surgical treatment for periprosthetic infection after primary TKA at the Mayo Clinic from 2000 to 2017. Treatment included placement of high-dose antibiotic-loaded bone cement (ABLC) spacers in addition to systemic antibiotics. Mean age was 67 years; 15% of patients had pre-existing chronic kidney disease (CKD). AKI was defined as a creatinine increase or 1.5 times baseline