• 1.

    National Institutes of Health. NIH. Guidelines on the Inclusion of Women and Minorities as Subjects in Clinical Research.. Fed Register 1994; 59:1450814513. https://grants.nih.gov/grants/guide/notice-files/not94-100.html#:~:text=guidelines%20on%20the%20inclusion%20of%20women%20and%20minorities,Act%20of%201993.%20EFFECTIVE%20DATE%3A%20March%209%2C%201994

    • Search Google Scholar
    • Export Citation
  • 2.

    Labots G, et al. Gender differences in clinical registration trials: Is there a real problem? Br J Clin Pharmacol 2018; 84:700707. doi: 10.1111/bcp.13497

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 3.

    Pilote L, Raparelli V. Participation of women in clinical trials: Not yet time to rest on our laurels. J Am Coll Cardiol 2018; 71:19701972. doi: 10.1016/j.jacc.2018.02.069

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 4.

    Bairey Merz CN, et al. Sex and the kidneys: Current understanding and research opportunities. Nat Rev Nephrol 2019; 15:776783. doi: 10.1038/s41581-019-0208-6

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 5.

    National Institutes of Health. Consideration of sex as a variable in NIH funded research. June 9, 2015. Notice number NOT-OD-15-102. https://grants.nih.gov/grants/guide/notice-files/not-od-15-102.html

    • Search Google Scholar
    • Export Citation
  • 6.

    Institute of Medicine (US) Committee on Understanding the Biology of Sex and Gender Differences; Wizemann TM, Pardue ML, editors. Exploring the Biological Contributions to Human Health: Does Sex Matter? Washington, DC, National Academies Press, 2001. https://www.ncbi.nlm.nih.gov/books/NBK222288/

    • Search Google Scholar
    • Export Citation
  • 7.

    Neugarten J, Golestaneh L. Influence of sex on the progression of chronic kidney disease. Mayo Clin Proc 2019; 94:13391356. doi: 10.1016/j.mayocp.2018.12.024

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 8.

    Ricardo AC, et al. Sex-related disparities in CKD progression. J Am Soc Nephrol 2019; 30:137146. doi: 10.1681/ASN.2018030296

  • 9.

    Gohar EY, et al. Evidence for G-protein-coupled estrogen receptor as a pronatriuretic factor. J Am Heart Assoc 2020; 18;9(10):e015110. doi: 10.1161/JAHA.119.015110

    • Search Google Scholar
    • Export Citation
  • 10.

    Mitchell T, et al. Sex differences in redox homeostasis in renal disease. Redox Biol 2020; 101489. doi: 10.1016/j.redox.2020.101489

  • 11.

    Lobo RA. Where are we 10 years after the Women's Health Initiative? J Clin Endocrinol Metab 2013; 98:17711780. doi: 10.1210/jc.2012-4070

  • 12.

    Parekh A, et al. Adverse effects in women: Implications for drug development and regulatory policies. Expert Rev Clin Pharmacol 2011; 4:453466. doi: 10.1586/ecp.11.29

    • Crossref
    • Search Google Scholar
    • Export Citation

Sex and Gender Differences Deserve More Study in Kidney Diseases

  • 1 Ruth Jessen Hickman, MD, is a graduate of the Indiana University School of Medicine. She is a freelance medical and science writer living in Bloomington, IN.
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