• 1.

    Suzuki H, et al.. The pathophysiology of IgA nephropathy. J Am Soc Nephrol 2011; 22:17951803. doi: 10.1681/ASN.2011050464

  • 2.

    Rauen T, et al.. Intensive supportive care plus immunosuppression in IgA nephropathy. N Engl J Med 2015; 373:22252236. doi: 10.1056/NEJMoa1415463

  • 3.

    Lv J, et al.. Effect of oral methylprednisolone on clinical outcomes in patients with IgA nephropathy: The TESTING randomized clinical trial. JAMA 2017; 318:432442. doi: 10.1001/jama.2017.9362

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 4.

    Tumlin JA, et al.. Idiopathic IgA nephropathy: Pathogenesis, histopathology, and therapeutic options. Clin J Am Soc Nephrol 2007; 2:10541061. doi: 10.2215/CJN.04351206

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 5.

    Rehnberg J, et al.. Inflammatory bowel disease is more common in patients with IgA nephropathy and predicts progression of ESKD: A Swedish population-based cohort study. J Am Soc Nephrol 2021; 32:411423. doi: 10.1681/ASN.2020060848

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6.

    Cheung CK, Barratt J. Gluten and IgA nephropathy: You are what you eat?. Kidney Int 2015; 88:215218. doi: 10.1038/ki.2015.149

  • 7.

    Barratt J, et al.. Exaggerated systemic antibody response to mucosal Helicobacter pylori infection in IgA nephropathy. Am J Kidney Dis 1999; 33:10491057. doi: 10.1016/S0272-6386(99)70141-1

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8.

    Hiki Y, et al.. Mass spectrometry proves under-O-glycosylation of glomerular IgA1 in IgA nephropathy. Kidney Int 2001; 59:10771085. doi: 10.1046/j.1523-1755.2001.0590031077.x

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9.

    Oortwijn BD, et al.. Demonstration of secretory IgA in kidneys of patients with IgA nephropathy. Nephrol Dial Transplant 2007; 22:31913195. doi: 10.1093/ndt/gfm346

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 10.

    Barratt J, et al.. Immune complex formation in IgA nephropathy: A case of the ‘right’ antibodies in the ‘wrong’ place at the ‘wrong’ time? Nephrol Dial Transplant 2009; 24:36203623. doi: 10.1093/ndt/gfp441

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 11.

    McCarthy DD, et al.. Mice overexpressing BAFF develop a commensal flora-dependent, IgA-associated nephropathy [published correction appears in J Clin Invest 2012; 122:778]. J Clin Invest 2011; 121:39914002. doi: 10.1172/JCI45563

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12.

    Chemouny JM, et al.. Modulation of the microbiota by oral antibiotics treats immunoglobulin A nephropathy in humanized mice. Nephrol Dial Transplant 2019; 34:11351144. doi: 10.1093/ndt/gfy323

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13.

    Kiryluk K, et al.. Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens. Nat Genet 2014; 46:11871196. doi: 10.1038/ng.3118

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14.

    De Angelis M, et al.. Microbiota and metabolome associated with immunoglobulin A nephropathy (IgAN). PLoS One 2014; 9:e99006. doi: 10.1371/journal.pone.0099006

  • 15.

    Fellström BC, et al.. Targeted-release budesonide versus placebo in patients with IgA nephropathy (NEFIGAN): A double-blind, randomised, placebo-controlled phase 2b trial. Lancet 2017; 389:21172127. doi: 10.1016/S0140-6736(17)30550-0

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 16.

    Selvaskandan H, et al.. New strategies and perspectives on managing IgA nephropathy. Clin Exp Nephrol 2019; 23:577588. doi: 10.1007/s10157-019-01700-1

IgA Nephropathy—Should We Target the Gut?

Chee Kay Cheung Chee Kay Cheung, MBChB, PhD, is a Consultant Nephrologist and Honorary Senior Lecturer at the University Hospitals of Leicester NHS Trust and University of Leicester, UK. Jonathan Barratt, PhD, FRCP, is the Mayer Professor of Renal Medicine and Honorary Consultant Nephrologist at the University of Leicester and University Hospitals of Leicester NHS Trust, UK.

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Jonathan Barratt Chee Kay Cheung, MBChB, PhD, is a Consultant Nephrologist and Honorary Senior Lecturer at the University Hospitals of Leicester NHS Trust and University of Leicester, UK. Jonathan Barratt, PhD, FRCP, is the Mayer Professor of Renal Medicine and Honorary Consultant Nephrologist at the University of Leicester and University Hospitals of Leicester NHS Trust, UK.

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