Corticosteroid Withdrawal after Kidney Transplant: 15-Year Follow-Up

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Long-term corticosteroid therapy may not be necessary in kidney transplant recipients receiving calcineurin-based immunosuppressive therapy, according to a clinical trial report in JAMA Surgery.

The researchers analyzed long-term follow-up data from a previous multi-center, randomized, double-blind trial including 385 adult patients undergoing living or deceased kidney transplantation between 1999 and 2002. All patients were classified at low-to-moderate immune risk and were free of delayed graft function or short-term rejection within the first week.

Patients were assigned to tacrolimus and mycophenolate mofetil, with or without corticosteroids, 7 days after transplantation. Outcomes were assessed via linkage to the national Organ Procurement