Chertow GM, et al. Effect of cinacalcet on cardiovascular disease in patients undergoing dialysis. N Engl J Med 2012; 367:2482−2494. doi: 10.1056/NEJMoa1205624
Block GA, et al. Effect of etelcalcetide vs placebo on serum parathyroid hormone in patients receiving hemodialysis with secondary hyperparathyroidism: Two randomized clinical trials. JAMA 2017; 317:146−155. doi: 10.1001/jama.2016.19456
Block GA, et al. Efficacy and safety of tenapanor in patients with hyperphosphatemia receiving maintenance hemodialysis: A randomized phase 3 trial. J Am Soc Nephrol 2019; 30:641−652. doi: 10.1681/ASN.2018080832
Ardelyx Ardelyx Announces Positive Topline Results from Pivotal Phase 3 PHREEDOM Study Evaluating Tenapanor in CKD Patients on Dialysis. Published December 3, 2019. Accessed December 25, 2020. https://ir.ardelyx.com/news-releases/news-release-details/ardelyx-announces-positive-topline-results-pivotal-phase-3
Block GA, et al. A pilot randomized trial of ferric citrate coordination complex for the treatment of advanced CKD. J Am Soc Nephrol 2019; 30:1495−1504. doi: 10.1681/ASN.2018101016
Edmonston DL, et al. Design and rationale of HiLo: A pragmatic, randomized trial of phosphate management for patients on maintenance hemodialysis. Am J Kidney Dis [published online ahead of print December 3, 2020]. doi: 10.1053/j.ajkd.2020.10.008; https://www.ajkd.org/article/S0272-6386(20)31131-8/fulltext
Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE). ClinicalTrials.gov: NCT03573089. https://clinicaltrials.gov/ct2/show/NCT03573089
Mineral bone disease (MBD) has proven to be a Pandora’s box for most clinicians treating chronic kidney disease (CKD), including end-stage kidney disease (ESKD). Although the body of literature highlighting the various bone metabolic abnormalities associated with ESKD as definite risk factors for mortality, cardiovascular disease, increased risk of fractures, and other musculoskeletal complications grows stronger, the therapeutic agents to deal with these abnormalities continue to keep us on edge (
Reasons for skepticism among nephrologists regarding novel drugs for MBD
In recent years, a few novel agents have