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Novel Agents in CKD-MBD A Second Lease on Life or Flogging a Dead Horse?

  • 1 Mayuri Trivedi, DM, is assistant professor, Nephrology Services, Department of Medicine, LTMGH, and consultant nephrologist and transplant physician, Hinduja Healthcare Surgical and S L Raheja Fortis Hospital, Mumbai, India. Sanjeev Nair, DM, is associate professor in the Department of Nephrology, Saveetha Medical College and Hospital, Chennai, India.
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Mineral bone disease (MBD) has proven to be a Pandora’s box for most clinicians treating chronic kidney disease (CKD), including end-stage kidney disease (ESKD). Although the body of literature highlighting the various bone metabolic abnormalities associated with ESKD as definite risk factors for mortality, cardiovascular disease, increased risk of fractures, and other musculoskeletal complications grows stronger, the therapeutic agents to deal with these abnormalities continue to keep us on edge (Table 1).

Reasons for skepticism among nephrologists regarding novel drugs for MBD

MBD = mineral bone disease

In recent years, a few novel agents have

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