PalmerBF, CleggDJ. Achieving the benefits of a high-potassium, paleolithic diet, without the toxicity. Mayo Clin Proc 2016; 91:496−508. doi: 10.1016/j.mayocp.2016.01.01210.1016/j.mayocp.2016.01.012)| false
Appropriate and timely management of hyperkalemia is an important component of a nephrology practice. Hyperkalemia can result from increased K+ intake in the diet, impaired distribution between intracellular and extracellular spaces, and decreased kidney excretion. Risk factors associated with the development of hyperkalemia include older age, male sex, diabetes, underlying kidney disease, as well as intake of certain medications that affect the renin angiotensin aldosterone system (RAAS).
Prior to the advent of sodium zirconium cyclosilicate (SZC) and patiromer, only sodium polystyrene sulfonate (SPS) was available as a potassium exchange resin (1). Approved by the