• Figure 1.

    Daratumumab-Based Treatment for Immunoglobulin Light-Chain Amyloidosis

  • 1.

    Lousada I, et al. Light chain amyloidosis: Patient experience survey from the Amyloidosis Research Consortium. Adv Ther 2015; 32:920928. doi: 10.1007/s12325-015-0250-0

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2.

    Dispenzieri A, et al. Prognostication of survival using cardiac troponins and N-terminal pro-brain natriuretic peptide in patients with primary systemic amyloidosis undergoing peripheral blood stem cell transplantation. Blood 2004; 104:18811887. doi: 10.1182/blood-2004-01-0390

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3.

    Palladini G, et al. A staging system for renal outcome and early markers of renal response to chemotherapy in AL amyloidosis. Blood 2014; 124:23252332. doi: 10.1182/blood-2014-04-570010

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 4.

    Venner CP, et al. Cyclophosphamide, bortezomib, and dexamethasone therapy in AL amyloidosis is associated with high clonal response rates and prolonged progression-free survival. Blood 2012; 119:43874390. doi: 10.1182/blood-2011-10-388462

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 5.

    Mikhael JR, et al. Cyclophosphamide-bortezomibdexamethasone (CyBorD) produces rapid and complete hematologic response in patients with AL amyloidosis. Blood 2012; 119:43914394. doi: 10.1182/blood-2011-11-390930

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6.

    Palladini G, et al. A European collaborative study of cyclophosphamide, bortezomib, and dexamethasone in upfront treatment of systemic AL amyloidosis. Blood 2015; 126:612615. doi: 10.1182/blood-2015-01-620302

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7.

    Kaufman GP, et al. Daratumumab yields rapid and deep hematologic responses in patients with heavily pretreated AL amyloidosis. Blood 2017; 130:900902. doi: 10.1182/blood-2017-01-763599

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8.

    Sanchorawala V, et al. Safety, tolerability, and response rates of daratumumab in relapsed AL amyloidosis: Results of a phase 2 study. Blood 2020; 135:15411547. doi: 10.1182/blood.2019004436

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9.

    Kastritis E, et al. Daratumumab-based treatment for immunoglobulin light-chain amyloidosis. N Engl J Med 2021; 385:4658. doi: 10.1056/NEJMoa2028631

  • 10.

    Palladini G, et al. Daratumumab plus CyBorD for patients with newly diagnosed AL amyloidosis: Safety run-in results of ANDROMEDA. Blood 2020; 136:7180. doi: 10.1182/blood.2019004460

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 11.

    Landau H, et al. Long-term event-free and overall survival after risk-adapted melphalan and SCT for systemic light chain amyloidosis. Leukemia 2017; 31:136142. doi: 10.1038/leu.2016.229

    • PubMed
    • Search Google Scholar
    • Export Citation

ANDROMEDA: Incorporating Daratumumab into Upfront Treatment for AL Amyloidosis Accelerates Therapeutic Progress by Light Years

Heather Landau Heather Landau is Director of the Amyloidosis Program with the Adult Bone Marrow Transplant Service, an Associate Member of the Memorial Sloan Kettering Cancer Center, and Associate Professor of Clinical Medicine with Weill Cornell Medical College, New York, NY.

Search for other papers by Heather Landau in
Current site
Google Scholar
PubMed
Close
Restricted access
Save