CKD patients have worse outcomes with opioids versus NSAIDs

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Among patients with CKD, those taking opioids have a higher rate of adverse outcomes than those taking nonsteroidal anti-inflammatory drugs (NSAIDs), reports a study in the American Journal of Kidney Diseases.

Using data from the Chronic Renal Insufficiency Cohort (CRIC), the researchers analyzed the relationship between analgesic use and clinical outcomes in patients with CKD. The analysis included 3939 CRIC participants with CKD not requiring kidney replacement therapy (KRT). The patients reported 30-day analgesic use at annual study visits. At baseline, 9.9% of patients were using opioids and 15.5% were taking NSAIDs.

Adverse outcomes were compared for groups

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