Early resolution of AKI leads to better long-term outcomes

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The first 72 hours after diagnosis of acute kidney injury (AKI) have a major impact on the long-term risk of kidney-specific outcomes, according to an analysis of prospective cohort data reported in JAMA Network Open.

The study included 1538 hospitalized patients from the prospective multicenter Assessment, Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury (ASSESS-AKI) study: 769 patients with AKI and 769 without. Participants were enrolled 3 months after hospital discharge between 2009 and 2015, with follow-up to 2018. The two groups were matched for demographic characteristics, hospital, comorbidity, and preadmission estimated glomerular filtration rate (eGFR).