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Exposure to nephrotoxic medications is a major cause of acute kidney injury (AKI) in hospitalized children, increasing the costs and length of hospital stays. In one study of pediatric patients not in the intensive care unit, 86% were exposed to a potentially nephrotoxic medication at some point during hospitalization (1). When children receive three or more nephrotoxic medications in the same day, the rates of AKI double (1). In some patients, the damage is permanent, leading to chronic kidney disease.
Stuart L. Goldstein, MD, director of the Center for Acute Care Nephrology at the Cincinnati Children’s