Perfusion Defects Have Larger Prognostic Impact in People with Diabetes

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Among patients with even minimal perfusion defects on quantitative single-photon emission computerized tomography (SPECT), the impact on risk of major adverse cardiovascular events (MACE) is significantly higher in those with diabetes, reports a study in Diabetes Care.

Data were drawn from the international, observational REgistry of Fast Myocardial Perfusion Imaging with NExt generation SPECT (REFINE SPECT) study. In that study, patients with known or suspected coronary artery disease underwent quantitative myocardial perfusion imaging using cadmium zinc telluride cameras. From the overall study population of more than 20,000 participants, the researchers identified propensity score–matched groups of 2951 patients with