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SGLT2s Show Promise for Kidney Protection Benefits Seen in Patients with and without Diabetes

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Results from 2 large clinical trials of sodium-glucose cotransporter 2 (SGLT2) inhibitors presented at the European Society of Cardiology (ESC) Congress 2020 show that the drugs may offer substantial kidney-protecting benefits.

The hotly awaited results of the Phase III Dapagliflozin And Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) trial showed a 39% reduction in a composite outcome of sustained reduction in estimated glomerular filtration rate of at least 50%, end stage kidney disease, or renal or cardiac death in patients taking the drug compared with patients taking a placebo (1). The trial, which was stopped early

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