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Farxiga Phase III DAPA-CKD trial will be stopped early after overwhelming efficacy in patients with chronic kidney disease. March 30, 2020. https://www.astrazeneca.com/media-centre/press-releases/2020/farxiga-phase-iii-dapa-ckd-trial-will-be-stopped-early-after-overwhelming-efficacy-in-patients-with-chronic-kidney-disease.html
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Results from 2 large clinical trials of sodium-glucose cotransporter 2 (SGLT2) inhibitors presented at the European Society of Cardiology (ESC) Congress 2020 show that the drugs may offer substantial kidney-protecting benefits.
The hotly awaited results of the Phase III Dapagliflozin And Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) trial showed a 39% reduction in a composite outcome of sustained reduction in estimated glomerular filtration rate of at least 50%, end stage kidney disease, or renal or cardiac death in patients taking the drug compared with patients taking a placebo (