• 1.

    Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Work Group. KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease–mineral and bone disorder (CKD-MBD). Kidney Int Suppl 2009; 76 (Suppl 113): S1130.

    • Search Google Scholar
    • Export Citation
  • 2.

    Ketteler M, et al. KDIGO 2017 clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of CKD-MBD. Kidney Int Suppl 2017; 7[Suppl 1]:159.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 3.

    Khairallah P, Nickolas TL. Management of osteoporosis in CKD. Clin J Am Soc Nephrol 2018; 13:962969.

  • 4.

    Pimentel A, et al. Fractures in patients with CKD—diagnosis, treatment, and prevention: A review by members of the European Calcified Tissue Society and the European Renal Association—European Dialysis and Transplant Association. Kidney Int 2017; 92:13431355.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 5.

    Isakova T, et al. Longitudinal FGF23 trajectories and mortality in patients with CKD. J Am Soc Nephrol 2018; 29:579590.

  • 6.

    Ross AC, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: What clinicians need to know. J Clin Endocrinol Metab 2011; 96:5358.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 7.

    Levin A, et al. Randomized controlled trial for the effect of vitamin D supplementation on vascular stiffness in CKD. Clin J Am Soc Nephrol 2017; 12:14471460.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 8.

    Kumar V, et al. A randomized trial of vitamin D supplementation on vascular function in CKD. J Am Soc Nephrol 2017; 28:31003108.

  • 9.

    Courbebaisse M, et al. Non-skeletal and skeletal effects of high doses versus minimum recommended intake of vitamin D3 in renal transplant recipients in a prospective, multicenter, double-blind, randomized study. Late Breaking Clinical Trial Abstract, ERA-EDTA Congress 2019, Budapest.

    • Search Google Scholar
    • Export Citation
  • 10.

    Sprague SM, et al. Use of extended-release calcifediol to treat secondary hyperparathyroidism in stages 3 and 4 chronic kidney disease. Am J Nephrol 2016; 44:316325.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 11.

    Strugnell SA, et al. Rationale for raising current clinical practice guideline target for serum 25-hydroxyvitamin D in chronic kidney disease. Am J Nephrol 2019; 49:284293.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 12.

    Cozzolino M, Ketteler M. Evaluating extended-release calcifediol as a treatment option for chronic kidney disease-mineral and bone disorder (CKD-MBD). Expert Opin Pharmacother. 2019; 20: 2081-2093.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 13.

    Scragg R, et al. Effect of monthly high-dose vitamin D supplementation on cardiovascular disease in the vitamin D assessment study: A randomized clinical trial. JAMA Cardiol 2017; 2:608616.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 14.

    Scragg R, et al. Monthly high-dose vitamin D supplementation and cancer risk: A post hoc analysis of the vitamin D assessment randomized clinical trial. JAMA Oncol 2018; 4:e182178.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 15.

    Manson JE, et al. Vitamin D supplements and prevention of cancer and cardiovascular disease. N Engl J Med 2019; 380:3344.

  • 16.

    de Boer IH, Zelnick LR, Ruzinski J, et al. Effect of vitamin D and omega-3 fatty acid supplementation on kidney function in patients with type 2 diabetes: A randomized clinical Trial. JAMA. 2019; doi: 10.1001/jama.2019.17380.

    • Crossref
    • Search Google Scholar
    • Export Citation

Chronic Kidney Disease–Mineral and Bone Disorder: Personal Perspective after the 2017 KDIGO CKD-MBD Guideline Update

  • 1 Markus Ketteler, MD, FERA, is the head of the Department of General Internal Medicine and Nephrology, Robert Bosch Hospital, Stuttgart, Germany.
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