Rituximab versus Cyclosporine for Membranous Nephropathy

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In patients with membranous nephropathy, rituximab is noninferior to cyclosporine in inducing remission, and superior in terms of maintaining proteinuria remission up to 2 years, reports a trial in The New England Journal of Medicine.

The randomized, open-label “Membranous Nephropathy Trial of Rituximab” (MENTOR) included 130 patients with membranous nephropathy enrolled at 22 North American centers. All had stable quantified creatinine clearance of 40 mL/min/1.73 m2 or higher and at least 3 months on angiotensin-system blockade. Patients were assigned to rituximab, two 1000 mg IV infusions given 14 days apart; or oral cyclosporine, starting dose 3.5