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Volume/Issue:
Volume 11: Issue 8
Page:
15–16
Publication Date:
01 Aug 2019
Online Publication Date:
05 Aug 2019
  • Figure 1.
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    Figure 1.

    Kidney outcomes in four major clinical trials evaluating glucagon-like peptide-1 receptor agonist medications in patients with type 2 diabetes.

Figure 1.

Kidney outcomes in four major clinical trials evaluating glucagon-like peptide-1 receptor agonist medications in patients with type 2 diabetes.
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    Pfeffer MA , et al.. Lixisenatide in patients with type 2 diabetes and acute coronary syndrome. N Engl J Med 2015; 373:2247–2257.

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    Mann JFE , et al.. Liraglutide and renal outcomes in type 2 diabetes. N Engl J Med 2017; 377:839–848.

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    Marso SP , et al.. Liraglutide and cardiovascular outcomes in type 2 diabetes. N Engl J Med 2016; 375:311–322.

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    Tuttle KR , et al.. Dulaglutide versus insulin glargine in patients with type 2 diabetes and moderate-to-severe chronic kidney disease (AWARD-7): a multicentre, open-label, randomised trial. Lancet Diabetes Endocrinol 2018; 6:605–617.

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    Marso SP , et al.. Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med 2016; 375:1834–1844.

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    American Diabetes Association. 9. Pharmacologic approaches to glycemic treatment: standards of medical care in diabetes–2019. Diabetes Care 2019; 42:S90–S102.

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    Tuttle KR , et al.. CKD outcomes in type 2 diabetes and moderate-to-severe CKD treated with dulaglutide versus insulin glargine: AWARD-7 [Poster]. JASN Kidney Week Edition Abstract Supplement 2018. 2018; Poster TH-OR033.

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    Mann JFE , et al.. Effects of liraglutide versus placebo on cardiovascular events in patients with type 2 diabetes mellitus and chronic kidney disease. Circulation 2018; 138:2908–2918.

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  • 9.

    Sun F , et al.. Impact of GLP-1 receptor agonists on blood pressure, heart rate and hypertension among patients with type 2 diabetes: a systematic review and network meta-analysis. Diabetes Res Clin Pract 2015; 110:26–37.

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  • 10.

    Potts JE , et al.. The effect of glucagon-like peptide 1 receptor agonists on weight loss in type 2 diabetes: a systematic review and mixed treatment comparison meta-analysis. PLoS One 2015; 10:e0126769.

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    Vilsboll T , et al.. Effects of glucagon-like peptide-1 receptor agonists on weight loss: systematic review and meta-analyses of randomised controlled trials. BMJ 2012; 344:d7771.

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  • 12.

    Dieter BP , Alicic RZ , Tuttle KR . GLP-1 receptor agonists in diabetic kidney disease: from the patient-side to the bench-side. Am J Physiol Renal Physiol 2018; 315:F1519–F1525.

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    Tanaka T , et al.. The potential for renoprotection with incretin-based drugs. Kidney Int 2014; 86:701–711.

Editorial Type:
Features

Emergence of GLP-1 Receptor Agonists as a Therapy for Diabetic Kidney Disease

Radica Z. Alicic Radica Z. Alicic, MD, FHM, FACP, is with Providence Health Care and the University of Washington School of Medicine. Emily J. Cox, PhD, is with Providence Health Care. Katherine R. Tuttle, MD, FACP, FASN, FNKF, is with Providence Health Care, the Kidney Research Institute, the Institute of Translational Health Sciences, and the University of Washington School of Medicine.

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Emily J. Cox Radica Z. Alicic, MD, FHM, FACP, is with Providence Health Care and the University of Washington School of Medicine. Emily J. Cox, PhD, is with Providence Health Care. Katherine R. Tuttle, MD, FACP, FASN, FNKF, is with Providence Health Care, the Kidney Research Institute, the Institute of Translational Health Sciences, and the University of Washington School of Medicine.

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Katherine R. Tuttle Radica Z. Alicic, MD, FHM, FACP, is with Providence Health Care and the University of Washington School of Medicine. Emily J. Cox, PhD, is with Providence Health Care. Katherine R. Tuttle, MD, FACP, FASN, FNKF, is with Providence Health Care, the Kidney Research Institute, the Institute of Translational Health Sciences, and the University of Washington School of Medicine.

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Volume/Issue:
Volume 11: Issue 8
Publication Date:
01 Aug 2019
Page:
15–16
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