Markers of Tubule Cell Dysfunction Predict AKI

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Among patients with chronic kidney disease (CKD), baseline biomarkers of tubule cell function are independent predictors of the later development of acute kidney injury (AKI), reports a study in Kidney International.

The researchers analyzed data on 2351 participants from the randomized Systolic Blood Pressure Intervention Trial (SPRINT). All had CKD (mean estimated glomerular filtration rate [eGFR] 49 mL/min/1.73 m2) and hypertension at baseline, but not diabetes. Participants were assigned intensive or standard systolic blood pressure targets: less than 120 versus less than 140 mm Hg. Study outcomes showed lower rates of cardiovascular disease and death with