High Dose of NSAIDs May Increase Kidney Disease Risk

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Exposure to high doses of nonsteroidal anti-inflammatory drugs (NSAIDs) shows a modest but significant association with kidney disease in a military population, reports a study in the open-access journal JAMA Network Open.

The retrospective analysis included data on more than 764,000 US Army soldiers on active duty from 2011 through 2014. Eighty-six percent of participants were men; median age was 27 years. Dispensing and dose of prescription NSAIDs were evaluated for association with incident diagnoses of acute kidney injury (AKI) and chronic kidney disease (CKD).

The participants received a total of 1.6 million distinct NSAID prescriptions during the