Survival Benefit of Kidney Transplant in Lupus Nephritis

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Kidney transplantation reduces mortality, mainly due to cardiovascular disease and infection, in patients with lupus nephritis, reports a study in Annals of Internal Medicine.

Through the United States Renal Data System, the researchers identified 20,974 individuals with kidney failure due to lupus nephritis (ESRD-LN) between 1995 and 2014. Of 9659 waitlisted patients, 5738 (59%) received a kidney transplant. Eighty-two percent of waitlisted patients were women and 60% were nonwhite.

Analyzed as a time-varying exposure, renal transplantation was associated with lower all-cause mortality among waitlisted patients: adjusted hazard ratio (HR) 0.30. There were also significant reductions in mortality due