Oxalate Excretion Linked to Risk of CKD Progression

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Higher urinary oxalate excretion is linked to an increased risk of progressive chronic kidney disease (CKD), reports a study in JAMA Internal Medicine.

The analysis included 3123 patients with stage 2 to 4 CKD, drawn from the Chronic Renal Insufficiency Study. Twenty-four-hour urinary oxalate excretion was measured at enrollment in 2003–08. Median oxalate excretion was 18.6 mg/24 hours; this value was inversely correlated with estimated glomerular filtration rate (eGFR) and positively correlated with 24-hour proteinuria.

Progression of CKD was evaluated in 2003–08, with a total follow-up of 22,318 person-years. At follow-up, 752 patients had developed end stage renal