New Combination for First-line Therapy of Advanced RCC

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Compared to sunitinib, a combination of avelumab plus axitinib improves progression-free survival in patients with advanced clear-cell renal cell carcinoma (RCC), reports a phase 3 randomized trial in The New England Journal of Medicine.

The industry-sponsored JAVELIN Renal 101 trial included 886 patients with previously untreated advanced RCC with a clear-cell component—the most common type of kidney cancer. Patients assigned to the intervention group received the immunotherapy drug avelumab plus the highly selective vascular endothelial growth factor (VEGF) receptor inhibitor axitinib. Those in the comparison group received the anti-VEGF agent sunitinib, which has been a standard treatment for

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