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Breath Gas, or “Exhalome,” Analysis of Volatile Organic Compounds Could Help Gauge AKI Severity

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Dozens of volatile organic compounds (VOCs) are found at elevated concentrations in expired gas from critically ill patients with acute kidney injury (AKI), reports a study in Critical Care Medicine.

The study included 20 mechanically ventilated patients with AKI, along with a control group of critically ill patients without AKI. The mechanically ventilated patients also had indications for dialysis.

Intensities of VOCs in breath samples were measured using multicapillary column ion-mobility spectrometry. Each patient’s “exhalome” was evaluated from 30 minutes before they started continuous venovenous hemodialysis through 7 hours after the start of dialysis.

The researchers hypothesized that

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