Obesity and related health risks, including diastolic blood pressure and fasting insulin level, are confirmed as risk factors for renal cell carcinoma (RCC), according to a study in the open-access journal PLoS Medicine.
Using a Mendelian randomization framework, the researchers analyzed gene variants associated with 13 obesity-related factors, identified from large-scale genome-wide association studies. The variants were used as proxies for measures of obesity, blood pressure, lipids, type 2 diabetes, insulin, and glucose. These factors were analyzed for association with the development of RCC in 10,784 cases and 20,406 controls. For each risk factor, odds ratios (ORs) for