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Volume/Issue:
Volume 11: Issue 3
Page:
11–12
Publication Date:
01 Mar 2019
Online Publication Date:
05 Mar 2019
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    Figure 1.

    Simplified design of a platform trial. One of the possibilities of a platform is to use biomarkers to stratify a large heterogeneous cohort of DKD patients to the most promising treatment options

Figure 1.

Simplified design of a platform trial. One of the possibilities of a platform is to use biomarkers to stratify a large heterogeneous cohort of DKD patients to the most promising treatment options
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    Ogurtsova K, et al.. IDF diabetes atlas: Global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res Clin Pract 2017; 128:40–50.

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    Thomas MC, Cooper ME, Zimmet P. Changing epidemiology of type 2 diabetes mellitus and associated chronic kidney disease. Nat Rev Nephrol 3026; 12:73–81.

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    Perco P, Mayer G. Molecular, histological, and clinical phenotyping of diabetic nephropathy: valuable complementary information? Kidney Int 2018; 93:308–310.

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    Heerspink HJL, Perkovic V. Trial design innovations to accelerate therapeutic advances in chronic kidney disease: Moving from single trials to an ongoing platform. Clin J Am Soc Nephrol 2018; 13:946–948.

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    Heerspink HJL, List J, Perkovic V. New clinical trial designs for establishing drug efficacy and safety in a precision medicine era. Diabetes Obes Metab 2018; 20[Suppl 3]:14–18.

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    Mayer B, et al.. Predictive biomarkers for linking disease pathology and drug effect. Curr Pharm Des 2017; 23:29–54.

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    Heinzel A, et al.. Validation of plasma biomarker candidates for the prediction of eGFR decline in patients with type 2 diabetes. Diabetes Care 2018; 41:1947–1954.

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    Ahlqvist E, et al.. Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables. Lancet Diabetes Endocrinol.

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Editorial Type:
Features

PRECISION MEDICINE in Diabetic Kidney Disease

Paul Perco Paul Perco, PhD, is associated with the Medical University, Innsbruck, Austria. Hiddo J. L. Heerspink, PhD, is associated with the University Medical Center, Groningen, Austria.

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Hiddo J. L. Heerspink Paul Perco, PhD, is associated with the Medical University, Innsbruck, Austria. Hiddo J. L. Heerspink, PhD, is associated with the University Medical Center, Groningen, Austria.

Search for other papers by Hiddo J. L. Heerspink in
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Volume/Issue:
Volume 11: Issue 3
Publication Date:
01 Mar 2019
Page:
11–12
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