Three different measures of adiposity are independent risk factors for decline in glomerular filtration rate (GFR) and death, concludes a meta-analysis in the British Medical Journal.
The analysis included individual-level data on nearly 5.5 million adults enrolled in 39 international general population cohorts, drawn from the Chronic Kidney Disease Prognosis Consortium. Eighteen cohorts included nearly 92,000 participants with CKD, while six cohorts included approximately 84,000 individuals at high cardiovascular risk. The study analyzed three indicators of adiposity: body mass index (BMI), waist circumference, and waist-to-height ratio. These measures were examined for association with decline in GFR—defined as eGFR