FGF-23 Does Not Predict Renal Function Decline in Older Adults

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Fibroblast growth factor 23 (FGF-23) does not consistently predict declining kidney function or development of CKD in healthy older adults, reports a study in Kidney International.

The analysis included 2496 well-functioning older adults, aged 70 to 79 years at baseline, enrolled in the prospective Healthy Aging and Body Composition study. Fifty-two percent of participants were women and 38% were black. Levels of FGF-23, measured using a commercial assay, were analyzed as a predictor of subsequent decline in kidney function and incident CKD (based on repeated measurements of cystatin C).

The median FGF-23 value was 46 pg/mL; participants with