Renal Denervation for Persistent Hypertension on Medications: Randomized Trial

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Renal denervation safely reduces blood pressure in patients with uncontrolled hypertension who continue taking antihypertensive medications, reports a trial in The Lancet.

The SPYRAL HTN-ON MED trial enrolled 487 adults with uncontrolled hypertension at 25 centers in Asia, Australia, Europe, and North America. All had uncontrolled hypertension, including an ambulatory systolic BP of 140 to 170 mm Hg despite at least 6 weeks on stable doses of one to three antihypertensive medications. After renal angiography, patients were randomly assigned to catheter-based renal denervation of the main renal arteries and branches or a sham procedure with sensory masking. All