Higher Rate of AKI with Restrictive Fluid Policy for Abdominal Surgery

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In patients undergoing major abdominal surgery, a restrictive fluid policy leads to an increased rate of acute kidney injury compared to liberal fluid therapy, while other outcomes are similar between groups, reports a study in The New England Journal of Medicine.

The “Restrictive versus Liberal Fluid Therapy in Major Abdominal Surgery” (RELIEF) trial included 3000 patients considered at increased risk of complications while undergoing major abdominal surgery. High-risk criteria included age 70 or older, heart disease, diabetes, renal impairment, and morbid obesity. The patients, enrolled at 47 centers in 7 countries, were randomly assigned to restrictive or liberal