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Volume/Issue:
Volume 10: Issue 6
Page:
21
Publication Date:
01 Jun 2018
Online Publication Date:
06 Jun 2018
  • Figure 1.
    View in gallery
    Figure 1.

    The simulation shows the students the size of the efferent and afferent arterioles, GFR values, capillary pressure, and the direction of the net pressure within Bowman’s capsule.

  • Figure 2.
    View in gallery
    Figure 2.

    When a student increases the blood pressure and makes the glomerular filtration barrier permeable to proteins, GFR is increased. Proteins can permeate this barrier and enter Bowman’s space in conditions such as diabetes and hypertension, which make oncotic and hydrostatic pressure additive forces in the Starling equation.

Figure 1.

The simulation shows the students the size of the efferent and afferent arterioles, GFR values, capillary pressure, and the direction of the net pressure within Bowman’s capsule.
Figure 2.

When a student increases the blood pressure and makes the glomerular filtration barrier permeable to proteins, GFR is increased. Proteins can permeate this barrier and enter Bowman’s space in conditions such as diabetes and hypertension, which make oncotic and hydrostatic pressure additive forces in the Starling equation.
  • 1.

    Stevens LA , Levey AS . Measurement of kidney function. Med Clin North Am 2005; 89:457–473.

  • 2.

    Hall JE , et al.. Control of glomerular filtration rate by renin-angiotensin system. Am J Physiol 1977; 233:F366–F372.

  • 3.

    Hostetter TH , Troy JL , Brenner BM . Glomerular hemodynamics in experimental diabetes mellitus. Kidney Int 1981; 19:410–415.

  • 4.

    Carlström M , Wilcox CS , Arendshorst WJ . Renal autoregulation in health and disease. Physiol Rev 2015; 95:405–511.

  • 5.

    Zhao L , et al.. High-salt diet induces outward remodelling of efferent arterioles in mice with reduced renal mass. Acta Physiol (Oxf) 2017; 219:654–661.

Editorial Type:
Features

Using a Computer Simulation to Teach Undergraduate Students the Principles Behind GFR Autoregulation

José J. Reyes-Tomassini José J. Reyes-Tomassini is a visiting assistant professor at Wartburg College in Waverly, Iowa.

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Volume/Issue:
Volume 10: Issue 6
Publication Date:
01 Jun 2018
Page:
21
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