Single Cell Gene Expression Studies Reveal Kidney Clues

  • 1 Jihwan Park, et al. Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease. Science 2018. DOI: 10.1126/science.aar2131
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A new genetic technique called single cell genetic sequencing is helping to reveal new insights about the cells that make up the kidney—insights that are essential to understanding what goes wrong in kidney disease and how it might be reversed.

Many types of cells make up the kidney, each with a distinct role in kidney health, making it a challenge for scientists to study. Traditionally, scientists have tried to distinguish these various cell types by their location in the kidney and appearance under a microscope, according to Katalin Susztak, MD, PhD, a professor of medicine at the Perelman School of