How Transplanted Livers Help Defend against Rejection in Multiple-Organ Transplantations

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A new study points to factors involved in the reduced likelihood of rejection in liver-kidney transplant recipients compared with solitary kidney transplant recipients.

“For many years, transplant physicians and researchers have known that the liver transplant recipients require less immunosuppression than the recipients of other organs, to prevent rejection,” said Timucin Taner, MD, PhD, a transplant surgeon at the Mayo Clinic and lead author of the Kidney International study. “This has been attributed to the liver being less immunogenic compared to the other commonly transplanted organs; however, the liver itself is an immunologically active organ, so we hypothesized