In CKD Patients with AF, Anticoagulation Increases Risks

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In older adults with chronic kidney disease (CKD), new anticoagulant therapy for atrial fibrillation (AF) is associated with increased risks of ischemic stroke and hemorrhage, reports a study in the British Medical Journal.

From a UK general practice database, the researchers identified 6977 CKD patients newly diagnosed with AF. Of these, 2434 were started on anticoagulation within 60 days. Propensity scores were used to create matched pairs of patients, exposed or not exposed to anticoagulant therapy. Mean age was about 82 years. At a median follow-up of 506 days, rates of ischemic stroke, cerebral or gastrointestinal bleeding, and