Review Questions Evidence on Statins for Non-CVD Outcomes

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There is a “dearth of convincing evidence” that lipid-lowering treatment with statin drugs plays any major role in improving outcomes other than cardiovascular disease (CVD), concludes a review and meta-analysis in Annals of Internal Medicine.

The researchers report an “umbrella” review of 268 previous meta-analyses of data on non-CVD outcomes of statin treatment. Their review identified 144 papers reporting 297 meta-analyses of randomized controlled trials (RCTs) and 112 papers reporting 268 meta-analyses of observational studies. The analysis examined a total of 278 unique non-CVD outcomes. It included credibility assessments incorporating summary effect sizes, study heterogeneity, 95% prediction intervals,