New Renal Week symposium honors Steven C. Hebert, who broke open black box of tubule cells

Steven C. Hebert, MD, the board-certified nephrologist and physician-scientist responsible for “breaking open the black box of tubule cells,” was honored at an ASN symposium featuring four former colleagues, who described recent studies that build upon Hebert’s pioneering research on the thick ascending limb’s function and dysfunction in kidney disease.

Serving as moderators of the inaugural Steven C. Hebert Memorial Symposium were Gerhard H. Giebisch, MD, professor emeritus of cellular and molecular physiology at Yale and Robert S. Hoover, MD, assistant professor of medicine at the

University of Chicago. Support for the session was provided by an educational grant from Amgen.

Speakers reported recent insights into the role of different NCKK2 isoforms, the regulation of the membrane transport protein NKCC2’s function by the WNK protein kinases and reactive oxygen species, and the role of the potassium channel ROMK in solute reabsorption. WNKs (with-no-lysine [K]) play a role in blood pressure control, and ROMK (renal outer medullary potassium) transports potassium out of cells.

The speakers were:

  • Jürgen B. Schnermann, MD, chief of the Kidney Disease Branch at the National Institute of Diabetes and Digestive and Kidney Diseases.
  • Gerardo Gamba, MD, PhD, professor of medicine at the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán and Instituto de Investigaciones Biomédicas, National University of Mexico.
  • Pablo A. Ortiz, PhD, associate professor at Henry Ford Hospital’s division of hypertension and vascular research in Detroit.
  • Tong Wang, MD, professor and director of Integrated Kidney Function Core at Yale.