Postdonation Hypertension, Diabetes May Affect ESRD Development and Risk of Death

Twenty-seven percent of kidney donors surveyed in a recent study reported at Kidney Week developed new-onset hypertension after donation.

Hassan Ibrahim, MD, FASN, of the University of Minnesota and his colleagues followed 3638 kidney donors for 13 +/− 11 years through surveys about hypertension and kidney disease, and also through laboratory testing. They found that predonation risk factors for development of hypertension included older age as well as higher BMI, systolic blood pressure, and serum glucose at donation. White donors were found to be 40 percent less likely to develop hypertension.

The team also found that kidney donors who developed hypertension had a nearly fourfold increased risk of premature death, proteinuria, and estimated glomerular filtration rate <30 mL/min or end stage renal disease (ESRD).

In a second study by Ibrahim and his colleagues, development of diabetes was determined in 3874 kidney donors who were followed for a mean of 16 +/− 12 years. Among the 7 percent who developed diabetes, predonation risk factors included older age, tobacco use, as well as higher BMI and fasting serum glucose.

The investigators also found that postdonation diabetes was associated with a twofold increase in ESRD and a nearly fivefold increase in proteinuria.

Ibrahim and his team used information from the studies to develop individualized risk calculators for development of postdonation hypertension and diabetes.

“ESRD and Post Donation Hypertension and Risk of Death and ESRD” (Abstract FR-OR069).

“Post Donation Diabetes and Risk of Death” (Abstract SA-PO1020).