Young Investigator Recognized for CKD Research

Janos Peti-Peterdi

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Janos Peti-Peterdi, MD, PhD, will receive the ASN-AHA Young Investigator Award for his groundbreaking research on CKD. He will describe his recent findings in an address: Renal Physiology Is Key to Understand and Augment Nephron Repair.

Dr. Peti-Peterdi is professor in the department of physiology and biophysics and the department of medicine at the University of Southern California (USC).

His laboratory at USC examines kidney and cardiovascular pathophysiology—specifically the mechanisms of the healthy kidney that maintain body fluid volume, electrolyte balance, and blood pressure—and how they are changed in disease.

A main goal is to identify the key molecular players in various renal pathologies as potential therapeutic targets. Dr. Peti-Peterdi’s group played an important role in identifying the cellular and molecular processes of a key anatomical site within the kidney—the juxtaglomerular apparatus or JGA—which controls the amount of blood flow and filtration through the kidneys.

Dr. Peti-Peterdi is director of the National Institutes of Health-funded Multi-Photon Microscopy Core at USC for high-resolution intravital (live animal or in vivo) imaging of intact organs in small laboratory animals. During the past decade, the laboratory pioneered several applications of intravital multiphoton microscopy that allow researchers to quantitatively visualize the most basic physiological parameters of kidney and nephron function. The Peti-Peterdi lab is using this imaging technology to examine complex regulatory and disease mechanisms in intact kidney tissue in various animal models.

Over the past five years, he has trained more than 30 investigators from around the world on the use of intravital imaging. Recent studies solved a critical technical barrier, allowing researchers for the first time to quantitatively visualize the function of glomerular cellular and molecular elements in vivo.

The Peti-Peterdi lab recently deployed serial multi-photon microscopy to track the fate and function of individual cells in the same region of the living intact kidney during disease development. This approach has led to significant advances in understanding the highly dynamic kidney tissue and glomerular environment and the mechanisms of glomerular injury and regeneration. The lab is also using renal stem cells to develop a regenerative approach to treat CKD.

Dr. Peti-Peterdi has served on committees for several associations and on the editorial boards of many journals. He is associate editor of the American Journal of Physiology—Renal Physiology.

He received his MD and PhD degrees from the Semmelweis University Medical School, Budapest, Hungary. He received his postdoctoral training in renal physiology and nephrology at the University of Alabama at Birmingham.