Findings

Even in mild cases with fast recovery, acute kidney injury (AKI) developing in the hospital is a strong risk factor for chronic kidney disease (CKD) at follow-up, reports a study in The American Journal of Kidney Diseases.

Patients who receive a kidney from an HLA-incompatible live donor have better survival than those who receive a deceased-donor transplant or who remain on the waiting list, concludes a study in The New England Journal of Medicine.

Adjuvant treatment with the oral antiangiogenic drugs sorafenib and sunitinib doesn’t improve survival after complete resection of non-metastatic renal cell carcinoma (RCC), reports a placebo-controlled trial in The Lancet.

Follow-up from a previous clinical trial shows improvements in kidney graft survival and function in patients receiving belatacept-based immunosuppression compared with those receiving cyclosporin, reports a study in The New England Journal of Medicine.

Patients with acute kidney injury (AKI) undergo a large number of tests, many of which are of limited clinical value, reports a study in BMC Nephrology (5).

The retrospective study included 5731 AKI episodes in 4903 adult inpatients at an academic medical center over 1 year. Rates of test performance and abnormal results were calculated for various urine, blood, radiologic, and pathology tests, including differences by AKI stage. Diagnostic yield was determined by manual review of electronic medical records.

A new online risk calculator can assess 15-year and lifetime risk of ESRD among potential living kidney donors, reports a study in The New England Journal of Medicine.

Three genetic variables are identified as predictors of chronic kidney disease (CKD) in Chinese patients with type 2 diabetes, according to a study in Kidney International.

The study used a new three-stage procedure to test the hypothesis that genetic variants associated with type 2 diabetes, obesity, and fasting plasma glucose might be associated with type 2 diabetes-related CKD. This process was carried out using a large clinicogenomic dataset from a prospective cohort of 2755 patients with type 2 diabetes from the Hong Kong Diabetes Registry.

For diabetic patients on metformin who require treatment intensification, adding insulin rather than sulfonylurea is associated with an increased risk of hypoglycemia, reports a study in the Canadian Medical Association Journal.

For high-risk patients with IgA nephropathy, adding immunosuppression to intensive supportive care doesn’t improve clinical outcomes—but does increase the rate of infections and other serious adverse effects, reports a trial in The New England Journal of Medicine.

Analysis of population-based data questions whether kidney transplant recipients are truly a “high-risk” group for fractures, reports a study in Transplantation.

Using Ontario healthcare databases, the researchers estimated cumulative rates of proximal humerus, forearm, and hip fractures at three, five, and ten years after kidney transplantation. These and other fracture outcomes were assessed in 4821 adult transplant recipients, median age 50 years, stratified by sex and age.

Pages