Findings

In individuals with or without hypertension, low urinary sodium excretion is associated with an increased risk of death and cardiovascular death, according to a controversial meta-analysis published in The Lancet

In patients with chronic kidney disease (CKD), high urinary sodium excretion is associated with an increased risk of cardiovascular events, concludes a study in The Journal of the American Medical Association

A high proportion of living kidney donors who have developed ESRD are never waitlisted for kidney transplantation, reports a study in Transplantation that was part of a special issue on living organ donation.

For patients with stage 3 acute kidney injury (AKI), early and delayed strategies for renal replacement therapy (RRT) yield similar mortality rates, concludes a randomized trial in The New England Journal of Medicine.

Middle-aged adults with prediabetes are at increased risk of developing glomerular hyperfiltration and albuminuria, reports a study in The American Journal of Kidney Diseases.

In critically ill patients with stage 2 AKI, early RRT leads to lower mortality compared with delayed RRT, reports a trial in The Journal of the American Medical Association

Residual kidney function (RKF) in dialysis patients can be estimated by equations based on serum measures of endogenous filtration markers, avoiding the need for prolonged timed urine collections, reports a study in Kidney International.

Even in more recent periods, HLA mismatches show a linear association with the outcomes of kidney allograft survival, concludes a study in Transplantation.

The analysis included more than 189,000 first adult, deceased-donor, kidney-only transplants performed in the US from 1987 through 2013. Number of HLA mismatches was evaluated for associated-with-kidney-allograft survival, with adjustment for recipient and donor characteristics.

Despite limitations of the current evidence base, preemptive kidney transplant programs “should be stimulated”—offering the option to consider transplantation before dialysis becomes necessary—concludes a systematic review and position statement published in Nephrology Dialysis Transplantation.

For patients undergoing heart surgery, treatment with rosuvastatin doesn’t reduce the rate of adverse outcomes, but is associated with an increased risk of postoperative acute kidney injury (AKI), according to a randomized trial in The New England Journal of Medicine.

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