Findings

Nearly two-thirds of children with type 1 diabetes hospitalized for diabetic ketoacidosis (DKA) will develop acute kidney injury (AKI), suggests a study in JAMA Pediatrics.

Currently available data cannot establish the safety and efficacy of osteoporosis medications for patients with chronic kidney disease (CKD), concludes a meta-analysis in Annals of Internal Medicine.

Two recent papers draw attention to some clinically significant health risks for patients with sickle cell trait (SCT)—an inherited blood disorder affecting up to 10% of African Americans.

African Americans with SCT have lower levels of hemoglobin A1c—which may place them at risk of delayed or missed diagnosis of diabetes and prediabetes, according to a study in the Journal of the American Medical Association (J Am Med Assoc 2017; 317:507–515).

Endophilin is critical to the development and maintenance of podocyte function in the kidney. This is the conclusion of Keita Soda, PhD, and co-workers from Yale University, who presented work at the Hot Science session at Kidney Week 2012 that described the connection between the protein endophilin and the synaptic proteins dynamin and synpatojanin 1, as well as the vital role endophilin plays in the formation and maintenance of the glomerular filtration barrier.

Although effects on relative versus absolute risk differ, low estimated glomerular filtration rate (eGFR) and high albuminuria are linked to increased mortality in all age groups, reports a study in The Journal of the American Medical Association.

The first genome-wide association study of antineutrophil cytoplasm antibody (ANCA)–associated vasculitis (AAV) has identified key genetic distinctions between the two major clinical syndromes of the disease. Although the syndromes—granulomatosis with polyangiitis and microscopic polyangiitis—can be differentiated in extreme versions, many patients “fall into the middle in sort of a gray zone where physicians classify them inconsistently,” said Kenneth Smith, MD, PhD, of the University of Cambridge.

A broadening donor pool, increased risk aversion, and inefficient organ allocation may all contribute to the long-term increase in the percentage of deceased donor kidneys discarded, concludes a study in Transplantation.

Intensive blood pressure control does not further reduce the risk of kidney disease progression among nondiabetic patients with kidney disease, concludes a meta-analysis in JAMA Internal Medicine.

In patients with chronic kidney disease (CKD), higher urine potassium excretion—as a surrogate for dietary potassium intake—is associated with a lower risk of death but no difference in the risk of kidney failure, reports a study in American Journal of Kidney Diseases.

Patients who have even relatively small increases in creatinine after starting angiotensin-converting enzyme inhibitor/angiotensin receptor blocker (ACEI/ARB) treatment are at increased risk of adverse cardiorenal events, suggests a study in the British Medical Journal.

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