Dietary Acid Load Linked to CKD Risk Factors

Higher dietary acid load is associated with albuminuria and other risk factors for chronic kidney disease (CKD), according to a report in BMC Nephrology.

The study included data from 12,293 adults participating in National Health and Nutrition Examination Surveys between 1999 and 2004. Diet-dependent acid load was assessed in terms of estimated net acid excretion (NAEes), based on nutrient intake and body surface area. Associations of NAEes with advanced stages of CKD, albuminuria, and sociodemographic and clinical characteristics were assessed.

Among adults aged 40 to 60 years, poverty, black race, and male sex were all associated with higher NAEes levels. Individuals with higher NAEes were more likely to have albuminuria than were those with lower levels: odds ratio 1.57. There was also a trend toward an increased risk of decreased estimated GFR among individuals with higher NAEes, which remained significant after adjustment for confounders.

Dietary factors can affect acid-base status, and they have a significant impact on the course and progression of CKD. These population-based data show that higher NAEes levels are associated with albuminuria and low eGFR in adults in the United States.

High dietary acid load is also associated with sociodemographic risk factors for CKD. The authors suggest the possibility of interventions to reduce dietary acid load in populations at high risk for CKD [Banerjee T, et al. Dietary acid load and chronic kidney disease among adults in the United States. BMC Nephrol 2014; 15:137].