Findings

Anti-inflammatory therapy with canakinumab—targeting the interleukin-1β (IL-1β) innate immunity pathway—reduces cardiovascular events in patients with previous myocardial infarction (MI), reports a trial in The New England Journal of Medicine.

Chronic hepatitis C virus (HCV) infection is associated with an increased risk of chronic kidney disease (CKD), with the extent of risk depending on viral load and genotype, reports a study in Kidney International.

For patients with acute myocardial infarction, nonadherence to beta blockers doesn’t reduce mortality—as long as they are taking their prescribed angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEIs/ARBs) and statins, reports a study in the Journal of the American College of Cardiology.

Glycated hemoglobin (HbA1c) levels may underestimate mean glucose level in African Americans with type 1 diabetes, reports a study in Annals of Internal Medicine.

Acute kidney injury (AKI) may be more frequent in ultramarathon runners who take ibuprofen, according to a randomized controlled trial in Emergency Medicine Journal.

Concentrations of four markers of filtration, individually and in combination, are consistently associated with the risk of progression to end stage renal disease (ESRD), reports a study in the American Journal of Kidney Diseases.

Contrast media exposure is not a “primary pathogenetic factor” in the development of acute kidney injury (AKI) after primary angioplasty, reports a study in the open-access Journal of the American Heart Association.

Particularly in interaction with donor age and pathway of death, total ischemic times of 14 hours or longer are associated with increased rates of adverse allograft outcomes in deceased donor kidney recipients, reports a study in Transplantation.

Especially in combination, quarter-dose medication regimens may provide a safe and effective alternative for blood pressure-lowering therapy, according to a meta-analysis in Hypertension.

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