Peters Award to Honor Thomas DuBose Jr.

Thomas D. DuBose Jr.

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ASN will recognize the wide-ranging contributions of Thomas D. DuBose Jr., MD, FASN, MACP, with the presentation of the John P. Peters Award.

Dr. DuBose is the Tinsley R. Harrison Chair of Internal Medicine and professor of physiology and pharmacology at Wake Forest School of Medicine in Winston-Salem, NC. The Peters Award is given for outstanding contributions to improving the lives of patients and to furthering the understanding of the kidney in health and disease, and Dr. Dubose’s achievements span the field from research to service.

Dr. DuBose has served as division chief of nephrology at two institutions, the University of Texas Medical Branch, Galveston, and the University of Texas Medical School, Houston. Prior to being recruited to Wake Forest, he was the Peter T. Bohan Professor and chair of the department of medicine at the University of Kansas School of Medicine.

Throughout his research career, Dr. DuBose has focused on elucidating factors governing the regulation of tubule transporters involved in urinary acidification and potassium homeostasis. These transporters have been implicated in monogenic diseases associated with renal tubular acidosis, the chronic metabolic acidosis of chronic progressive kidney disease, and abnormalities in potassium balance and blood pressure regulation.

His studies with Dr. David Good at the University of Texas uncovered the interdependence of potassium homeostasis and ammonium excretion. Their studies in animal models provided a better understanding of the role of hyperkalemia in the development of metabolic acidosis and of hypokalemia in the perpetuation of metabolic alkalosis, underscoring the importance of the correction of these conditions for treatment.

His studies using microelectrode methodology validated the reliability of the urine minus blood CO2 tension as an index of distal tubule H+-secretion in the rat collecting duct, and extended these observations to experimental models of distal renal tubular acidosis. He and his colleagues were among the first to show that while both gastric and colonic α -subunits of H+,K+-ATPase play a role in urinary acidification in the kidney, the colonic α H+,K+-ATPase is site-specifically upregulated in the collecting duct by potassium deprivation in an animal model of chronic hypokalemia. These studies showed the importance of this proton transporter in the metabolic alkalosis associated with hypokalemia.

Dr. DuBose is an author of 164 published papers and chapters in textbooks. With Dr. Lee Hamm he co-edited the text Acid-Base and Electrolyte Disorders.

Dr. DuBose served as ASN president in 2006. He has also served the society as chair of the Chronic Kidney Disease Advisory Group, a member of the board of advisors, and as its representative on the Council of Subspecialty Societies of the American College of Physicians. He chaired the American Heart Association Council on the Kidney in Cardiovascular Disease and served as a member of the board of regents of the American College of Physicians.

He has also received the Donald W. Seldin Award and the President’s Award of the National Kidney Foundation, and the Distinguished Achievement Award of the American Heart Association Council on the Kidney in Cardiovascular Disease.

John P. Peters

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John P. Peters, MD, was one of the fathers of nephrology and former chief of the Metabolic Division in the Department of Medicine at Yale University. He transformed clinical chemistry from a discipline of qualitative impressions to one in which precise quantitative measurements of body fluids comprise a vital part of the patient examination and provide great explanatory value.

He advanced the view that disease is a quantitative abnormality of normal physiological processes and that, by understanding disease, one could gain a deeper understanding of normal physiology. His enduring scientific contributions paralleled his fervent mission to ensure that the physician be an advocate for the patient.


October-November 2012 (Vol. 4, Number 10 & 11)