Regulation of Sodium Transporters Will Be Lecture Subject

Alicia M. McDonough, PhD

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Alicia M. McDonough, PhD, will discuss “Inflammatory Cytokines Regulate Proximal and Distal Sodium Transporters” in the Robert W. Schrier, MD, Endowed Lectureship on Friday, Nov. 3.

Dr. McDonough is professor of integrative anatomical sciences at the Keck School of Medicine of the University of Southern California (USC) in Los Angeles. Upon joining the USC faculty in 1981, she began studying the assembly of sodium pump subunits and defining the molecular mechanisms of sodium pump isoform regulation in cardiac and skeletal muscle by potassium and hormones. The McDonough lab initiated studies to determine the renal mechanisms responsible for regulation of sodium, potassium, and blood pressure balance as well as how homeostasis is disrupted in disease states and can be corrected therapeutically.

The lab recently investigated ion transporters’ phosphorylation, abundance, subcellular distribution, and activity. The researchers’ findings have enabled them to define how stimuli such as dietary sodium and potassium, angiotensin II, cytokines, and injury increase renal sodium transport, as well as how the resultant hypertension decreases sodium reabsorption via pressure natriuresis. To pursue these projects, the McDonough lab has engaged with collaborators across the United States. and around the world.

Dr. McDonough has published extensively and given many lectures on these topics. She has received the Established Investigator Award from the American Heart Association (AHA), the E.H. Starling Distinguished Lectureship from the American Physiological Society (APS), the Donald Seldin Lectureship from the AHA Council on the Kidney in Cardiovascular Disease, and several teaching awards.

She serves on several editorial boards, study sections, and committees for the ASN, APS, and AHA.

Dr. McDonough earned her doctorate in physiology at the University of Hawaii and was a postdoctoral scholar at the University of California, San Francisco, Cardiovascular Research Institute and Columbia University.

October/November 2017 (Vol. 9, Number 10 & 11)