Small Changes in Blood Acidity May Affect CKD Patients’ Health

New research suggests very small changes in blood pH levels may affect renal calcium reabsorption and parathyroid hormone (PTH) secretion. In both human embryonic kidney cells and bovine parathyroid cells, decreasing the extracellular pH from 7.4 to 7.2 rapidly inhibited intracellular calcium mobilization through the calcium-sensing receptor, whereas raising extracellular pH to 7.6 increased responsiveness to extracellular calcium. Also, pH elevation suppressed PTH secretion from human parathyroid cells, while acidosis increased PTH secretion. The JASN findings suggest that acid-base disturbances may affect the control of parathyroid function and calcium metabolism.

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New research suggests very small changes in blood pH levels may affect renal calcium reabsorption and parathyroid hormone (PTH) secretion. In both human embryonic kidney cells and bovine parathyroid cells, decreasing the extracellular pH from 7.4 to 7.2 rapidly inhibited intracellular calcium mobilization through the calcium-sensing receptor, whereas raising extracellular pH to 7.6 increased responsiveness to extracellular calcium. Also, pH elevation suppressed PTH secretion from human parathyroid cells, while acidosis increased PTH secretion. The JASN findings suggest that acid-base disturbances may affect the control of parathyroid function and calcium metabolism.

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